You have to leave the factory radio in place regardless. Your bluetooth system, and severall other controls are integrated into the JBL unit. You can purchase an aftermarket adapter that will connect your factory radio into an aftermarket car ampllifier. I did this on my 08 highlander. However, I have a gas engine, so it can easliy power up my amplifier. Hence, the question would be can a Hybrid accomadate an aftemarket amplifier?